Systematically identifying genetic signatures including novel SNP-clusters, nonsense variants, frame-shift INDELs, and long STR expansions that potentially link to unknown phenotypes existing in dog breeds

Abstract Background In light of previous studies that profiled breed-specific traits or used genome-wide association studies to refine loci associated with characteristic morphological features in dogs, the field has gained tremendous genetic insights for known dog traits observed among breeds.Here we aim to address the question from a reserve pers

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Epidemiology of major lower limb amputation using routinely collected electronic health data in the UK: a systematic review protocol

Introduction It is estimated that peripheral arterial disease occurs in one in five people aged over 60 years in the UK.Major lower limb amputation is a debilitating and life-changing potential outcome of peripheral arterial disease.A number of risk factors are involved in the development of the disease including smoking and diabetes.There is debat

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